Tyr981
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Home > Phosphorylation Site Page: > Tyr981  -  Ret (human)

Site Information
DNCSEEMyRLMLQCW   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450703

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry (in vitro) ( 4 ) , mutation of modification site ( 3 , 5 , 7 ) , phospho-antibody ( 2 , 5 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
'neuron, superior cervical ganglion'-brain [Ret (mouse), homozygous knockout] ( 3 ) , 293 (epithelial) ( 2 , 5 ) , 3T3 (fibroblast) ( 7 )

Upstream Regulation
Regulatory protein:
Ret (human) ( 2 )
Putative in vivo kinases:
Ret (human) ( 5 )
Kinases, in vitro:
Ret (human) ( 6 )
Treatments:
GDNF ( 5 ) , imatinib ( 2 ) , PP1 ( 2 ) , sorafenib ( 2 )

Downstream Regulation
Effects of modification on Ret:
enzymatic activity, induced ( 7 ) , molecular association, regulation ( 5 )
Induce interaction with:
Src (human) ( 5 )

References 

1

Plaza-Menacho I, et al. (2016) RET Functions as a Dual-Specificity Kinase that Requires Allosteric Inputs from Juxtamembrane Elements. Cell Rep 17, 3319-3332
28009299   Curated Info

2

Plaza-Menacho I, et al. (2011) Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism. J Biol Chem 286, 17292-302
21454698   Curated Info

3

Encinas M, et al. (2008) Analysis of Ret knockin mice reveals a critical role for IKKs, but not PI 3-K, in neurotrophic factor-induced survival of sympathetic neurons. Cell Death Differ 15, 1510-21
18497757   Curated Info

4

Knowles PP, et al. (2006) Structure and chemical inhibition of the RET tyrosine kinase domain. J Biol Chem 281, 33577-87
16928683   Curated Info

5

Encinas M, Crowder RJ, Milbrandt J, Johnson EM (2004) Tyrosine 981, a novel ret autophosphorylation site, binds c-Src to mediate neuronal survival. J Biol Chem 279, 18262-9
14766744   Curated Info

6

Kawamoto Y, et al. (2004) Identification of RET autophosphorylation sites by mass spectrometry. J Biol Chem 279, 14213-24
14711813   Curated Info

7

Kato M, et al. (2002) Repair by Src kinase of function-impaired RET with multiple endocrine neoplasia type 2A mutation with substitutions of tyrosines in the COOH-terminal kinase domain for phenylalanine. Cancer Res 62, 2414-22
11956105   Curated Info