Ser668
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Home > Phosphorylation Site Page: > Ser668  -  HIF1A (human)

Site Information
DTQSRTAsPNRAGkG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 11073382

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 1 , 3 ) , mutation of modification site ( 2 ) , western blotting ( 2 )
Disease tissue studied:
colorectal cancer ( 2 ) , colorectal carcinoma ( 2 ) , melanoma skin cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
CDK1 (human) ( 2 )

Downstream Regulation
Effects of modification on HIF1A:
protein stabilization ( 2 )
Effects of modification on biological processes:
cell growth, induced ( 2 ) , cell motility, induced ( 2 )

References 

1

Bassani-Sternberg M, et al. (2016) Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry. Nat Commun 7, 13404
27869121   Curated Info

2

Warfel NA, et al. (2013) CDK1 stabilizes HIF-1α via direct phosphorylation of Ser668 to promote tumor growth. Cell Cycle 12, 3689-701
24189531   Curated Info

3

Moritz A (2009) CST Curation Set: 7295; Year: 2009; Biosample/Treatment: cell line, MKN-45/-; Disease: gastric carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS/T) (110B7) Rabbit mAb Cat#: 9614, PTMScan(R) Phospho-Akt Substrate Motif (RXXS*/T*) Immunoaffinity Beads Cat#: 1978
Curated Info