Ser651
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Home > Phosphorylation Site Page: > Ser651  -  GPIbA (human)

Site Information
SIRYSGHsL______   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450660

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 6 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 3 , 4 , 5 ) , phospho-antibody ( 3 , 4 , 6 ) , phosphoamino acid analysis ( 5 ) , western blotting ( 3 , 4 , 5 )
Disease tissue studied:
breast cancer ( 1 ) , breast cancer, triple negative ( 1 )
Relevant cell line - cell type - tissue:
'muscle, skeletal' ( 2 ) , breast ( 1 ) , CHO (fibroblast) ( 3 , 4 , 5 ) , platelet-blood ( 5 , 6 )

Upstream Regulation
Treatments:
von_Willebrand_factor ( 5 )

Downstream Regulation
Effects of modification on GPIbA:
molecular association, regulation ( 3 , 6 )
Induce interaction with:
14-3-3 sigma (human) ( 4 ) , 14-3-3 zeta (human) ( 3 , 6 )

References 

1

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

2

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

3

Mu FT, Cranmer SL, Andrews RK, Berndt MC (2010) Functional association of phosphoinositide-3-kinase with platelet glycoprotein Ibalpha, the major ligand-binding subunit of the glycoprotein Ib-IX-V complex. J Thromb Haemost 8, 324-30
19874472   Curated Info

4

Mu FT, et al. (2008) A functional 14-3-3zeta-independent association of PI3-kinase with glycoprotein Ib alpha, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complex. Blood 111, 4580-7
18299448   Curated Info

5

Mangin P, et al. (2004) Identification of a novel 14-3-3zeta binding site within the cytoplasmic tail of platelet glycoprotein Ibalpha. Blood 104, 420-7
15054037   Curated Info

6

Bodnar RJ, et al. (1999) The cytoplasmic domain of the platelet glycoprotein Ibalpha is phosphorylated at serine 609. J Biol Chem 274, 33474-9
10559231   Curated Info