Ser843
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Home > Phosphorylation Site Page: > Ser843  -  mGluR2 (rat)

Site Information
GSAAPRAsANLGQGS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450654

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 ) , mutation of modification site ( 1 ) , peptide sequencing ( 1 ) , phosphopeptide mapping ( 1 )
Relevant cell line - cell type - tissue:
'neuron, cerebellar granule'-brain ( 1 ) , CHO (fibroblast) [EphB1 (human), transfection] ( 1 )

Upstream Regulation
Putative in vivo kinases:
PKACA (rat) ( 1 )
Kinases, in vitro:
PKACA (rat) ( 1 )
Treatments:
cAMP_analog ( 1 ) , colforsin ( 1 ) , H-89 ( 1 )

Downstream Regulation
Effects of modification on mGluR2:
activity, inhibited ( 1 ) , molecular association, regulation ( 1 )
Inhibit interaction with:
G-alpha 15 (human) ( 1 )

References 

1

Schaffhauser H, et al. (2000) cAMP-dependent protein kinase inhibits mGluR2 coupling to G-proteins by direct receptor phosphorylation. J Neurosci 20, 5663-70
10908604   Curated Info