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Site Information |
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GPGDTTStFCGTPNY SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 447510 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
Relevant cell line - cell type - tissue: |
Upstream Regulation | |
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Putative in vivo kinases: | |
Kinases, in vitro: | |
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Downstream Regulation | |
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Effects of modification on PKCZ: | |
Effects of modification on biological processes: | |
Induce interaction with: |
References | |
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Willis CL, Meske DS, Davis TP (2010) Protein kinase C activation modulates reversible increase in cortical blood-brain barrier permeability and tight junction protein expression during hypoxia and posthypoxic reoxygenation. J Cereb Blood Flow Metab 30, 1847-59
20700133 Curated Info |
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Wu SC, Solaro RJ (2007) Protein kinase C zeta. A novel regulator of both phosphorylation and de-phosphorylation of cardiac sarcomeric proteins. J Biol Chem 282, 30691-8
17724026 Curated Info |
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Kelly MT, Crary JF, Sacktor TC (2007) Regulation of protein kinase Mzeta synthesis by multiple kinases in long-term potentiation. J Neurosci 27, 3439-44
17392460 Curated Info |
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Mouton V, et al. (2007) Evaluation of the role of protein kinase Czeta in insulin-induced heart 6-phosphofructo-2-kinase activation. Cell Signal 19, 52-61
16829026 Curated Info |
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Le Good JA, Brindley DN (2004) Molecular mechanisms regulating protein kinase Czeta turnover and cellular transformation. Biochem J 378, 83-92
14580237 Curated Info |
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Powell DJ, Hajduch E, Kular G, Hundal HS (2003) Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism. Mol Cell Biol 23, 7794-808
14560023 Curated Info |
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Lornejad-Schäfer MR, et al. (2003) Osmotic regulation of insulin-induced mitogen-activated protein kinase phosphatase (MKP-1) expression in H4IIE rat hepatoma cells. Biochem J 371, 609-19
12529177 Curated Info |
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Rafty LA, Khachigian LM (2001) Sp1 phosphorylation regulates inducible expression of platelet-derived growth factor B-chain gene via atypical protein kinase C-zeta. Nucleic Acids Res 29, 1027-33
11222751 Curated Info |
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Standaert ML, et al. (2001) Insulin and PIP3 activate PKC-zeta by mechanisms that are both dependent and independent of phosphorylation of activation loop (T410) and autophosphorylation (T560) sites. Biochemistry 40, 249-55
11141077 Curated Info |
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Le Good JA, et al. (1998) Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science 281, 2042-5
9748166 Curated Info |