Lys128

Site Information
DLVLDDSkRVAkRkL GenPept Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 10769107

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 1 ) , modification-specific antibody ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:	3T3 (fibroblast) ( 1 ) , GH4C1 (pituitary cell) ( 1 ) , HEK293T (epithelial) ( 1 ) , HeLa (cervical) ( 1 )

Downstream Regulation
Effects of modification on TR-alpha:	molecular association, regulation ( 1 )
Effects of modification on biological processes:	carcinogenesis, inhibited ( 1 ) , transcription, altered ( 1 )
Induce interaction with:	ACTR1A (human) ( 1 ) , DNA ( 1 )
Inhibit interaction with:	SMRT (human) ( 1 )

References
1	Sánchez-Pacheco A, Martínez-Iglesias O, Méndez-Pertuz M, Aranda A (2009) Residues K128, 132, and 134 in the thyroid hormone receptor-alpha are essential for receptor acetylation and activity. Endocrinology 150, 5143-52 19819978 Curated Info