Tyr856
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Home > Phosphorylation Site Page: > Tyr856  -  PDGFRB (mouse)

Site Information
DIMRDSNyISkGSTF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447509

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 ) , mutation of modification site ( 4 ) , phospho-antibody ( 2 , 3 , 4 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
GLRX1 (mouse) ( 2 ) , PTP1B (mouse) ( 1 )
Kinases, in vitro:
PDGFRB (mouse) ( 4 )
Treatments:
PDGF ( 1 , 2 , 3 , 4 )

References 

1

Mertins P, et al. (2008) Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomics. Mol Cell Proteomics 7, 1763-77
18515860   Curated Info

2

Xing K, et al. (2007) Low molecular weight protein tyrosine phosphatase (LMW-PTP) and its possible physiological functions of redox signaling in the eye lens. Biochim Biophys Acta 1774, 545-55
17428749   Curated Info

3

Nickas ME, Bernard A, Kazlauskas A (2001) The requirement of tyrosines 579 and 581 for maximal ligand-dependent activation of the betaPDGFR is influenced by noncytoplasmic regions of the receptor. Exp Cell Res 265, 80-9
11281646   Curated Info

4

Fantl WJ, Escobedo JA, Williams LT (1989) Mutations of the platelet-derived growth factor receptor that cause a loss of ligand-induced conformational change, subtle changes in kinase activity, and impaired ability to stimulate DNA synthesis. Mol Cell Biol 9, 4473-8
2479827   Curated Info