Ser491
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Home > Phosphorylation Site Page: > Ser491  -  AMPKA2 (human)

Site Information
stPQRsCsAAGLHRP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450432

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 3 , 5 , 7 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
HER2 positive breast cancer ( 3 ) , luminal A breast cancer ( 3 ) , luminal B breast cancer ( 3 ) , breast cancer, surrounding tissue ( 3 ) , breast cancer, triple negative ( 3 ) , leukemia ( 2 ) , T cell leukemia ( 2 ) , lung cancer ( 7 ) , non-small cell lung cancer ( 7 ) , pancreatic ductal adenocarcinoma ( 5 )
Relevant cell line - cell type - tissue:
'pancreatic, ductal'-pancreas ( 5 ) , 293 (epithelial) ( 1 ) , breast ( 3 ) , HeLa (cervical) ( 1 ) , HUVEC (endothelial) ( 1 ) , Jurkat (T lymphocyte) ( 2 ) , NCI-H1650 (pulmonary) ( 7 )

Upstream Regulation
Treatments:
Akt_inhibitor_VIII ( 1 ) , anti-CD3 ( 2 ) , H-89 ( 2 ) , PD184352 ( 1 ) , VEGF ( 1 )

Downstream Regulation
Effects of modification on biological processes:
autophagy, altered ( 2 )

References 

1

Heathcote HR, et al. (2016) Protein kinase C phosphorylates AMP-activated protein kinase α1 Ser487. Biochem J 473, 4681-4697
27784766   Curated Info

2

Corrado M, et al. (2016) Macroautophagy inhibition maintains fragmented mitochondria to foster T cell receptor-dependent apoptosis. EMBO J 35, 1793-809
27390127   Curated Info

3

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

4

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

5

Britton D, et al. (2014) Quantification of pancreatic cancer proteome and phosphorylome: indicates molecular events likely contributing to cancer and activity of drug targets. PLoS One 9, e90948
24670416   Curated Info

6

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

7

Possemato A (2010) CST Curation Set: 9738; Year: 2010; Biosample/Treatment: cell line, H1650/Phenformin; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST]
Curated Info