Ser1044
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Home > Phosphorylation Site Page: > Ser1044  -  LIFR (human)

Site Information
WNLVsPDsPRsIDSN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450385

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 7 ) , electrophoretic mobility shift ( 6 ) , immunoassay ( 1 ) , immunoprecipitation ( 1 ) , mass spectrometry ( 1 , 2 , 3 ) , mutation of modification site ( 1 , 4 , 5 , 6 , 7 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
brain cancer ( 5 ) , liver cancer ( 6 ) , neuroblastoma ( 4 , 5 ) , prostate cancer ( 1 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 7 ) , ESC ( 2 ) , H-35 (hepatic) ( 6 , 7 ) , HEK293T (epithelial) ( 2 ) , HeLa (cervical) ( 3 ) , HepG2 (hepatic) ( 6 ) , NBFL ( 4 , 5 ) , PC3 (prostate cell) ( 1 ) , VCap (prostate cell) ( 1 )

Upstream Regulation
Regulatory protein:
ERK1 (human) ( 4 ) , ERK2 (human) ( 1 , 4 )
Putative in vivo kinases:
ERK1 (human) ( 6 , 7 ) , ERK2 (human) ( 1 , 6 , 7 )
Kinases, in vitro:
ERK1 (human) ( 7 ) , ERK2 (human) ( 7 )
Treatments:
Akt_inhibitor_X ( 1 ) , CHIR99021 ( 2 ) , EGF ( 5 , 7 ) , insulin ( 7 ) , LIF ( 2 , 7 ) , LY3214996 ( 1 ) , PD0325901 ( 2 ) , PD98059 ( 5 ) , phorbol_ester ( 7 ) , SC1 ( 1 ) , ulixertinib ( 1 )

Downstream Regulation
Effects of modification on LIFR:
activity, induced ( 1 ) , activity, inhibited ( 7 ) , intracellular localization ( 6 ) , protein degradation ( 5 , 6 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell adhesion, induced ( 1 ) , cell growth, induced ( 1 ) , cell motility, induced ( 1 ) , signaling pathway regulation ( 1 ) , transcription, inhibited ( 4 )

Disease / Diagnostics Relevance
Relevant diseases:
prostate cancer ( 1 )

References 

1

Shao J, et al. (2019) Phosphorylation of LIFR promotes prostate cancer progression by activating the AKT pathway. Cancer Lett 451, 110-121
30851421   Curated Info

2

Wang XJ, et al. (2017) Opposing Roles of Acetylation and Phosphorylation in LIFR-Dependent Self-Renewal Growth Signaling in Mouse Embryonic Stem Cells. Cell Rep 18, 933-946
28122243   Curated Info

3

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

4

Nathanson NM (2012) Regulation of neurokine receptor signaling and trafficking. Neurochem Int 61, 874-8
22306348   Curated Info

5

Port MD, Laszlo GS, Nathanson NM (2008) Transregulation of leukemia inhibitor factor receptor expression and function by growth factors in neuroblastoma cells. J Neurochem 106, 1941-51
18624908   Curated Info

6

Blanchard F, et al. (2000) Stimulation of leukemia inhibitory factor receptor degradation by extracellular signal-regulated kinase. J Biol Chem 275, 28793-801
10858440   Curated Info

7

Schiemann WP, et al. (1995) Phosphorylation of the human leukemia inhibitory factor (LIF) receptor by mitogen-activated protein kinase and the regulation of LIF receptor function by heterologous receptor activation. Proc Natl Acad Sci U S A 92, 5361-5
7777512   Curated Info

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