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Site Information |
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KLMIVGNtGsGKttL SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 10426319 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
Disease tissue studied: | |
Relevant cell line - cell type - tissue: |
Upstream Regulation | |
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Kinases, in vitro: |
Downstream Regulation | |
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Effects of modification on LRRK2: | |
Inhibit interaction with: |
References | |
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Law BM, et al. (2014) A Direct Interaction between Leucine-rich Repeat Kinase 2 and Specific β-Tubulin Isoforms Regulates Tubulin Acetylation. J Biol Chem 289, 895-908
24275654 Curated Info |
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Sheng Z, et al. (2012) Ser1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations. Sci Transl Med 4, 164ra161
23241745 Curated Info |
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Webber PJ, et al. (2011) Autophosphorylation in the Leucine-Rich Repeat Kinase 2 (LRRK2) GTPase Domain Modifies Kinase and GTP-Binding Activities. J Mol Biol 412, 94-110
21806997 Curated Info |
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Gloeckner CJ, et al. (2010) Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2. J Proteome Res 9, 1738-45
20108944 Curated Info |
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Pungaliya PP, et al. (2010) Identification and Characterization of a Leucine-Rich Repeat Kinase 2 (LRRK2) Consensus Phosphorylation Motif. PLoS One 5, e13672
21060682 Curated Info |
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Greggio E, et al. (2009) The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites. Biochem Biophys Res Commun 389, 449-54
19733152 Curated Info |