Tyr447

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Home > Phosphorylation Site Page: > Tyr447 - Brk (mouse)

Site Information
KLTGITRyENLV___ SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 450276

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:	HeLa (cervical) ( 1 ) , NMuMG (epithelial) ( 1 )

Downstream Regulation
Effects of modification on Brk:	enzymatic activity, inhibited ( 1 )
Effects of modification on biological processes:	RNA stability, altered ( 1 )
Induce interaction with:	KHDRBS1 (human) ( 1 )

References
1	Derry JJ, et al. (2000) Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability. Mol Cell Biol 20, 6114-26 10913193 Curated Info

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