Tyr662
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Home > Phosphorylation Site Page: > Tyr662  -  CD6 (human)

Site Information
DSTDNDDyDDISAA_   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450239

In vivo Characterization
Methods used to characterize site in vivo:
flow cytometry ( 1 ) , immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
leukemia ( 1 ) , T cell leukemia ( 1 )
Relevant cell line - cell type - tissue:
Jurkat (T lymphocyte) ( 1 , 2 ) , lymphocyte ( 1 )

Upstream Regulation
Treatments:
anti-CD3 ( 2 )

Downstream Regulation
Effects of modification on CD6:
activity, induced ( 1 ) , molecular association, regulation ( 1 )
Induce interaction with:
GADS (human) ( 1 ) , SLP76 (human) ( 1 )

References 

1

Breuning J, Brown MH (2017) T Cell Costimulation by CD6 Is Dependent on Bivalent Binding of a GADS/SLP-76 Complex. Mol Cell Biol 37
28289074   Curated Info

2

Kobarg J, et al. (1997) Analysis of the tyrosine phosphorylation and calcium fluxing of human CD6 isoforms with different cytoplasmatic domains. Eur J Immunol 27, 2971-80
9394826   Curated Info