Ser51
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Home > Phosphorylation Site Page: > Ser51  -  SNX27 (human)

Site Information
VRIVksEsGYGFNVR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 486072

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 , 2 , 3 , 5 , 6 , 7 , 8 , 11 , 12 , 13 , 14 , 15 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
HER2 positive breast cancer ( 3 ) , luminal A breast cancer ( 3 ) , luminal B breast cancer ( 3 ) , breast cancer, surrounding tissue ( 3 ) , breast cancer, triple negative ( 3 ) , lung cancer ( 12 ) , non-small cell lung cancer ( 12 ) , melanoma skin cancer ( 7 )
Relevant cell line - cell type - tissue:
'stem, embryonic' ( 15 ) , 293 (epithelial) [AT1 (human), transfection, AT1R stable transfected HEK293] ( 14 ) , 293GP (epithelial) [NPM-ALK (human), transfection] ( 13 ) , breast ( 3 ) , H2077 (pulmonary) ( 12 ) , H322M (pulmonary) ( 12 ) , HEK293T (epithelial) ( 1 , 6 ) , HeLa (cervical) ( 1 , 8 , 11 ) , K562 (erythroid) ( 11 ) , MCF-7 (breast cell) ( 5 ) , NCI-H1568 (pulmonary) ( 12 ) , NCI-H520 (squamous) ( 12 ) , NCI-H647 (pulmonary) ( 12 ) , PC9 (pulmonary) ( 12 ) , Vero E6-S ('epithelial, kidney') ( 2 ) , WM239A (melanocyte) ( 7 )

Upstream Regulation
Regulatory protein:
MKK6 (human) ( 1 )
Putative in vivo kinases:
P38A (human) ( 1 ) , P38B (human) ( 1 )
Kinases, in vitro:
P38A (human) ( 1 ) , P38B (human) ( 1 )
Treatments:
ATP ( 1 ) , bafilomycin_A ( 1 ) , CCCP ( 1 ) , EBSS ( 1 ) , EGF ( 1 ) , IL-6 ( 1 ) , JNK_inhibitor_VIII ( 1 ) , LPS ( 1 ) , metformin ( 5 ) , SB202190 ( 1 ) , SB203580 ( 1 ) , siRNA ( 1 ) , thapsigargin ( 1 ) , U0126 ( 1 )

Downstream Regulation
Effects of modification on SNX27:
molecular association, regulation ( 1 ) , protein conformation ( 1 ) , receptor recycling, inhibited ( 1 )
Inhibit interaction with:
DGKZ (human) ( 1 ) , PTHR (human) ( 1 ) , SEMA4C (human) ( 1 )

References 

1

Mao L, et al. (2021) Phosphorylation of SNX27 by MAPK11/14 links cellular stress-signaling pathways with endocytic recycling. J Cell Biol 220
33605979   Curated Info

2

Bouhaddou M, et al. (2020) The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell 182
32645325   Curated Info

3

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

4

Boeing S, et al. (2016) Multiomic Analysis of the UV-Induced DNA Damage Response. Cell Rep 15, 1597-1610
27184836   Curated Info

5

Sacco F, et al. (2016) Deep Proteomics of Breast Cancer Cells Reveals that Metformin Rewires Signaling Networks Away from a Pro-growth State. Cell Syst 2, 159-71
27135362   Curated Info

6

Franchin C, et al. (2015) Quantitative analysis of a phosphoproteome readily altered by the protein kinase CK2 inhibitor quinalizarin in HEK-293T cells. Biochim Biophys Acta 1854, 609-23
25278378   Curated Info

7

Stuart SA, et al. (2015) A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics 14, 1599-615
25850435   Curated Info

8

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

9

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

10

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

11

Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71
23186163   Curated Info

12

Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68
22617229   Curated Info

13

Wu F, et al. (2010) Studies of phosphoproteomic changes induced by nucleophosmin-anaplastic lymphoma kinase (ALK) highlight deregulation of tumor necrosis factor (TNF)/Fas/TNF-related apoptosis-induced ligand signaling pathway in ALK-positive anaplastic large cell lymphoma. Mol Cell Proteomics 9, 1616-32
20393185   Curated Info

14

Christensen GL, et al. (2010) Quantitative phosphoproteomics dissection of seven-transmembrane receptor signaling using full and biased agonists. Mol Cell Proteomics 9, 1540-53
20363803   Curated Info

15

Brill LM, et al. (2009) Phosphoproteomic analysis of human embryonic stem cells. Cell Stem Cell 5, 204-13
19664994   Curated Info

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