Lys270
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Home > Ubiquitylation Site Page: > Lys270  -  AQP2 (mouse)

Site Information
QsLPRGskA______   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 999601

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
MDCK (epithelial) ( 2 ) , mIMCD-3 (epithelial) ( 1 )

Upstream Regulation
Treatments:
GW3965 ( 1 ) , T0901317 ( 1 )

Downstream Regulation
Effects of modification on AQP2:
protein stabilization ( 1 ) , ubiquitination ( 2 )

References 

1

Su W, et al. (2017) Liver X receptor β increases aquaporin 2 protein level via a posttranscriptional mechanism in renal collecting ducts. Am J Physiol Renal Physiol 312, F619-F628
28052875   Curated Info

2

Moeller HB, et al. (2014) Phosphorylation and ubiquitylation are opposing processes that regulate endocytosis of the water channel aquaporin-2. J Cell Sci 127, 3174-83
24876223   Curated Info

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