Lys270
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Home > Ubiquitylation Site Page: > Lys270  -  AQP2 (human)

Site Information
QsLPRGtkA______   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 999601

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:

Downstream Regulation
Effects of modification on AQP2:
intracellular localization ( 1 ) , phosphorylation ( 1 ) , protein degradation ( 1 )

References 

1

Boone M, et al. (2011) Counteracting vasopressin-mediated water reabsorption by ATP, dopamine, and phorbol esters: mechanisms of action. Am J Physiol Renal Physiol 300, F761-71
21209006   Curated Info

2

van Balkom BW, et al. (2009) LIP5 interacts with aquaporin 2 and facilitates its lysosomal degradation. J Am Soc Nephrol 20, 990-1001
19357255   Curated Info

3

Kamsteeg EJ, et al. (2008) Missorting of the Aquaporin-2 mutant E258K to multivesicular bodies/lysosomes in dominant NDI is associated with its monoubiquitination and increased phosphorylation by PKC but is due to the loss of E258. Pflugers Arch 455, 1041-54
17965877   Curated Info