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| Site Information |
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| NAMKKLGsKKPQKPI SwissProt Entrez-Gene |
| Blast this site against: NCBI SwissProt PDB |
| Site Group ID: 9993604 |
| In vivo Characterization | |
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| Methods used to characterize site in vivo: | |
| Relevant cell line - cell type - tissue: | |
| Upstream Regulation | |
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| Regulatory protein: | |
| Putative in vivo kinases: | |
| Kinases, in vitro: | |
| Downstream Regulation | |
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| Effects of modification on SCN5A: | |
| References | |
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Matasic DS, et al. (2020) Modulation of the cardiac sodium channel Na1.5 peak and late currents by NAD precursors. J Mol Cell Cardiol 141, 70-81
32209328 Curated Info |
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Herren AW, et al. (2015) CaMKII Phosphorylation of Na(V)1.5: Novel in Vitro Sites Identified by Mass Spectrometry and Reduced S516 Phosphorylation in Human Heart Failure. J Proteome Res 14, 2298-311
25815641 Curated Info |
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Hallaq H, et al. (2012) Activation of protein kinase C alters the intracellular distribution and mobility of cardiac Na+ channels. Am J Physiol Heart Circ Physiol 302, H782-9
22101522 Curated Info |
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Valdivia CR, Ueda K, Ackerman MJ, Makielski JC (2009) GPD1L links redox state to cardiac excitability by PKC-dependent phosphorylation of the sodium channel SCN5A. Am J Physiol Heart Circ Physiol 297, H1446-52
19666841 Curated Info |
