Tyr138

Site Information
TGYIPSNyVAPSDSI SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 450213

In vivo Characterization
Methods used to characterize site in vivo:	[32P] bio-synthetic labeling ( 1 ) , mutation of modification site ( 1 , 2 ) , phosphoamino acid analysis ( 1 ) , phosphopeptide mapping ( 1 )
Relevant cell line - cell type - tissue:	3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 1 ) , MEF (fibroblast) [IGF1R (mouse)] ( 1 ) , MEF (fibroblast) ( 2 )

Downstream Regulation
Effects of modification on biological processes:	cell cycle regulation ( 2 ) , cell growth, altered ( 2 )

References
1	Broome MA, Hunter T (1997) The PDGF receptor phosphorylates Tyr 138 in the c-Src SH3 domain in vivo reducing peptide ligand binding. Oncogene 14, 17-34 9010229 Curated Info
2	Broome MA, Hunter T (1996) Requirement for c-Src catalytic activity and the SH3 domain in platelet-derived growth factor BB and epidermal growth factor mitogenic signaling. J Biol Chem 271, 16798-806 8663329 Curated Info