Ser1388
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Home > Phosphorylation Site Page: > Ser1388  -  TSC2 (mouse)

Site Information
QPLSKssssPELQTL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450212

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
AMPKA1 (mouse) ( 1 )
Treatments:
metformin ( 1 )

Downstream Regulation
Effects of modification on TSC2:
phosphorylation ( 1 )
Effects of modification on biological processes:
signaling pathway regulation ( 1 ) , transcription, altered ( 1 ) , translation, inhibited ( 1 )

References 

1

Van Nostrand JL, et al. (2020) AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation. Genes Dev 34, 1330-1344
32912901   Curated Info

2

Zibrova D, et al. (2017) GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis. Biochem J 474, 983-1001
28008135   Curated Info

3

Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. Nat Commun 7, 13250
27841257   Curated Info

4

Gwinn DM, et al. (2008) AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 30, 214-26
18439900   Curated Info