Tyr246
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Home > Phosphorylation Site Page: > Tyr246  -  DMAP1 (human)

Site Information
EQVAEEEyLLQELRK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 998916

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 , 3 , 4 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
lung cancer ( 2 , 3 , 4 ) , non-small cell lung cancer ( 3 , 4 ) , non-small cell lung adenocarcinoma ( 2 ) , pancreatic cancer ( 1 ) , pancreatic carcinoma ( 1 )
Relevant cell line - cell type - tissue:
lung ( 3 , 4 ) , PANC-1 (pancreatic) ( 1 ) , PC9 (pulmonary) ( 2 ) , PC9-IR (pulmonary) ( 2 ) , SW1990 (pancreatic) ( 1 )

Upstream Regulation
Putative in vivo kinases:
Src (human) ( 1 )
Kinases, in vitro:
Src (human) ( 1 )
Treatments:
SU6656 ( 1 )

Downstream Regulation
Effects of modification on DMAP1:
methylation ( 1 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 ) , carcinogenesis, induced ( 1 ) , transcription, induced ( 1 )
Inhibit interaction with:
BUB3 (human) ( 1 ) , DNA ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
pancreatic carcinoma ( 1 )

References 

1

Li J, et al. (2018) C-Src confers resistance to mitotic stress through inhibition DMAP1/Bub3 complex formation in pancreatic cancer. Mol Cancer 17, 174
30553276   Curated Info

2

Tsai CF, et al. (2015) Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics. Nat Commun 6, 6622
25814448   Curated Info

3

Guo A (2006) CST Curation Set: 1770; Year: 2006; Biosample/Treatment: tissue, lung/-; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

4

Guo A (2006) CST Curation Set: 1678; Year: 2006; Biosample/Treatment: tissue, lung/-; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

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