Ser178
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Home > Phosphorylation Site Page: > Ser178  -  p27Kip1 (mouse)

Site Information
EENVsDGsPNAGtVE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450208

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 7 ) , mass spectrometry ( 1 , 3 , 4 , 6 ) , mass spectrometry (in vitro) ( 5 ) , mutation of modification site ( 7 )
Disease tissue studied:
anthrax infection ( 6 )
Relevant cell line - cell type - tissue:
'3T3-L1, differentiated' (adipocyte) ( 4 ) , E.coli (bacterial) ( 5 ) , liver ( 1 ) , MC3T3-E1 (preosteoblast) ( 3 ) , mesangial ( 7 ) , spleen ( 6 )

Upstream Regulation
Kinases, in vitro:
IKKA (mouse) ( 5 )

Downstream Regulation
Effects of modification on biological processes:
cell cycle regulation ( 7 ) , cell growth, altered ( 7 )

References 

1

Robles MS, Humphrey SJ, Mann M (2017) Phosphorylation Is a Central Mechanism for Circadian Control of Metabolism and Physiology. Cell Metab 25, 118-127
27818261   Curated Info

2

Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. Nat Commun 7, 13250
27841257   Curated Info

3

Williams GR, et al. (2016) Exploring G protein-coupled receptor signaling networks using SILAC-based phosphoproteomics. Methods 92, 36-50
26160508   Curated Info

4

Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
23684622   Curated Info

5

Zhang W, et al. (2013) A NIK-IKK╬▒ Module Expands ErbB2-Induced Tumor-Initiating Cells by Stimulating Nuclear Export of p27/Kip1. Cancer Cell 23, 647-59
23602409   Curated Info

6

Manes NP, et al. (2011) Discovery of mouse spleen signaling responses to anthrax using label-free quantitative phosphoproteomics via mass spectrometry. Mol Cell Proteomics 10, M110.000927
21189417   Curated Info

7

Wolf G, et al. (2003) Erk 1,2 phosphorylates p27(Kip1): Functional evidence for a role in high glucose-induced hypertrophy of mesangial cells. Diabetologia 46, 1090-9
12856081   Curated Info