Lys426
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Home > Acetylation Site Page: > Lys426  -  WSTF (human)

Site Information
GNSKSPKkGLktPkT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 9905197

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 ) , modification-specific antibody ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 1 ) , breast adenocarcinoma ( 1 ) , breast cancer, triple negative ( 1 )
Relevant cell line - cell type - tissue:
breast ( 1 ) , BT-474 (breast cell) ( 1 ) , BT-549 (breast cell) ( 1 ) , HEK293T (epithelial) ( 1 ) , Hs 578T (breast cell) ( 1 ) , MCF-7 (breast cell) ( 1 ) , MDA-MB-231 (breast cell) ( 1 ) , MDA-MB-453 (breast cell) ( 1 ) , MDA-MB-468 (breast cell) ( 1 ) , NCI-H2228 (pulmonary) ( 3 ) , T47D (breast cell) ( 1 )

Upstream Regulation
Regulatory protein:
SIRT2 (human) ( 1 )
Treatments:
nicotinamide ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on WSTF:
enzymatic activity, induced ( 1 ) , molecular association, regulation ( 1 ) , phosphorylation ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell growth, induced ( 1 ) , transcription, induced ( 1 )
Induce interaction with:
H2AX (human) ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
breast cancer ( 1 )

References 

1

Liu Y, et al. (2020) WSTF acetylation by MOF promotes WSTF activities and oncogenic functions. Oncogene 39, 5056-5067
32518374   Curated Info

2

Choudhary C, et al. (2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 325, 834-40
19608861   Curated Info

3

Rikova K (2008) CST Curation Set: 5646; Year: 2008; Biosample/Treatment: cell line, NCI-H2228/DMSO; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK Antibodies Used to Purify Peptides prior to LCMS: Acetylated-Lysine (Ac-K2-100) Rabbit mAb Cat#: 9814, PTMScan(R) Acetyl-Lys Motif (Ac-K) Immunoaffinity Beads Cat#: 1989
Curated Info

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