Lys154
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Home > Ubiquitylation Site Page: > Lys154  -  p21Cip1 (human)

Site Information
MTDFyHskRrLIFSk   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 9897005

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 4 )
Disease tissue studied:
bone cancer ( 4 )
Relevant cell line - cell type - tissue:

Downstream Regulation
Effects of modification on p21Cip1:
protein degradation ( 4 ) , ubiquitination ( 4 )

References 

1

Boeing S, et al. (2016) Multiomic Analysis of the UV-Induced DNA Damage Response. Cell Rep 15, 1597-1610
27184836   Curated Info

2

Arakawa T, et al. (2010) IL-1-induced ERK1/2 activation up-regulates p21(Waf1/Cip1) protein by inhibition of degradation via ubiquitin-independent pathway in human melanoma cells A375. Biochem Biophys Res Commun 392, 369-372
20074553   Curated Info

3

Fu D, Richardson DR (2007) Iron chelation and regulation of the cell cycle: 2 mechanisms of posttranscriptional regulation of the universal cyclin-dependent kinase inhibitor p21CIP1/WAF1 by iron depletion. Blood 110, 752-61
17429006   Curated Info

4

Bendjennat M, et al. (2003) UV irradiation triggers ubiquitin-dependent degradation of p21(WAF1) to promote DNA repair. Cell 114, 599-610
13678583   Curated Info