Ser364
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Home > Phosphorylation Site Page: > Ser364  -  GJA1 (human)

Site Information
AIVDQRPssRAssRA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450183

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 2 ) , mass spectrometry ( 1 ) , mutation of modification site ( 2 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:
HMLER ('stem, breast cancer') [CXCR4 (human), knockdown] ( 1 ) , HMLER ('stem, breast cancer') ( 1 )

Upstream Regulation
Kinases, in vitro:
PKACA (human) ( 2 )

Downstream Regulation
Effects of modification on GJA1:
protein conformation ( 2 )

References 

1

Yi T, et al. (2014) Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells. Proc Natl Acad Sci U S A 111, E2182-90
24782546   Curated Info

2

Grosely R, et al. (2013) Effects of Phosphorylation on the Structure and Backbone Dynamics of the Intrinsically Disordered Connexin43 C-terminal Domain. J Biol Chem 288, 24857-70
23828237   Curated Info

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