Ser364
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Home > Phosphorylation Site Page: > Ser364  -  GJA1 (rat)

Site Information
AIVDQRPssRAssRA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450183

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 5 ) , immunoprecipitation ( 5 ) , mass spectrometry ( 1 , 2 , 4 ) , mass spectrometry (in vitro) ( 3 ) , mutation of modification site ( 5 )
Relevant cell line - cell type - tissue:
'brain, brainstem' ( 2 ) , 'brain, cerebellum' ( 2 ) , 'brain, cerebral cortex' ( 2 ) , heart ( 2 , 4 ) , intestine ( 2 ) , KO ( 5 ) , myocardium ( 1 ) , spleen ( 2 ) , stomach ( 2 ) , T51B (epithelial) ( 5 ) , testis ( 2 )

Upstream Regulation
Kinases, in vitro:
CAMK2A (human) ( 3 ) , PKCA (human) ( 4 ) , PKCE (human) ( 4 )
Treatments:
cAMP_analog ( 5 ) , hypoxia ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
ventricular tachycardia ( 1 )

References 

1

Kohutova J, et al. (2018) Anti-arrhythmic Cardiac Phenotype Elicited by Chronic Intermittent Hypoxia Is Associated With Alterations in Connexin-43 Expression, Phosphorylation, and Distribution. Front Endocrinol (Lausanne) 9, 789
30740090   Curated Info

2

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

3

Huang RY, et al. (2011) Identification of CaMKII phosphorylation sites in Connexin43 by high-resolution mass spectrometry. J Proteome Res 10, 1098-109
21158428   Curated Info

4

Axelsen LN, et al. (2006) Identification of ischemia-regulated phosphorylation sites in connexin43: A possible target for the antiarrhythmic peptide analogue rotigaptide (ZP123). J Mol Cell Cardiol 40, 790-8
16678851   Curated Info

5

TenBroek EM, et al. (2001) Ser364 of connexin43 and the upregulation of gap junction assembly by cAMP. J Cell Biol 155, 1307-18
11756479   Curated Info

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