Ser498
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Home > Phosphorylation Site Page: > Ser498  -  BACE (human)

Site Information
DDFADDIsLLk____   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450178

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 5 , 6 ) , immunoprecipitation ( 1 , 6 ) , mutation of modification site ( 1 , 2 , 4 , 5 , 6 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
Alzheimer's disease ( 2 ) , neuroblastoma ( 1 , 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
PAR3 (human) ( 1 )
Kinases, in vitro:
CK1A (human) ( 5 ) , CK1D (human) ( 6 ) , ROCK2 (human) ( 2 )
Treatments:
CK1-7 ( 5 ) , okadaic_acid ( 6 ) , PKC-theta_pseudosubstrate ( 1 )

Downstream Regulation
Effects of modification on BACE:
enzymatic activity, induced ( 2 ) , intracellular localization ( 1 , 4 , 6 )
Induce interaction with:
PACS-1 (human) ( 1 )
Inhibit interaction with:
Rab7 (human) ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
Alzheimer's disease ( 1 )

References 

1

Sun M, Zhang H (2017) Par3 and aPKC regulate BACE1 endosome-to-TGN trafficking through PACS1. Neurobiol Aging 60, 129-140
28946017   Curated Info

2

Herskowitz JH, et al. (2013) Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model. J Neurosci 33, 19086-98
24305806   Curated Info

3

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

4

He X, Li F, Chang WP, Tang J (2005) GGA proteins mediate the recycling pathway of memapsin 2 (BACE). J Biol Chem 280, 11696-703
15615712   Curated Info

5

Pastorino L, et al. (2002) The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total A(beta). Mol Cell Neurosci 19, 175-85
11860271   Curated Info

6

Walter J, et al. (2001) Phosphorylation regulates intracellular trafficking of beta-secretase. J Biol Chem 276, 14634-41
11278841   Curated Info