Ser1303

Site Information
NKLRRQHsyDtFVDL SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 450171

In vivo Characterization
Methods used to characterize site in vivo:	[32P] bio-synthetic labeling ( 49 ) , immunoprecipitation ( 15 ) , mass spectrometry ( 7 , 12 , 15 , 16 , 20 , 21 , 22 , 23 , 24 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ) , microscopy-colocalization with upstream kinase ( 48 ) , mutation of modification site ( 48 ) , peptide sequencing ( 49 ) , phospho-antibody ( 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 13 , 14 , 17 , 18 , 19 , 45 , 46 , 49 ) , phosphoamino acid analysis ( 49 ) , phosphopeptide mapping ( 12 ) , western blotting ( 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 13 , 14 , 17 , 18 , 19 )
Relevant cell line - cell type - tissue:	'brain, brainstem' ( 16 ) , 'brain, cerebellum' ( 16 ) , 'brain, cerebral cortex' ( 5 , 14 , 16 ) , 'brain, hippocampus' ( 5 , 6 , 14 ) , 'brain, hypothalamus' ( 5 ) , 'brain, nucleus accumbens' ( 14 ) , 'brain, striatum' ( 6 , 14 , 46 ) , 'brain, visual cortex' ( 19 ) , 'neuron, cortical'-brain ( 2 , 6 ) , 'neuron, hippocampal'-brain ( 3 ) , 'neuron, hippocampal, CA1 pyramidal'-brain ( 8 ) , 293 (epithelial) ( 48 ) , brain ( 7 , 9 , 13 , 18 , 20 , 21 , 22 , 23 , 24 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ) , esophagus ( 17 ) , neuron-'brain, cerebral cortex' ( 10 ) , neuron-'brain, hippocampus' ( 4 , 15 , 49 ) , neuron-spinal cord ( 11 ) , neuron:synaptosome-brain ( 12 ) , retina ( 19 ) , spinal cord ( 45 )

In vivo Characterization

Methods used to characterize site in vivo:

[32P] bio-synthetic labeling ( 49 ) , immunoprecipitation ( 15 ) , mass spectrometry ( 7 , 12 , 15 , 16 , 20 , 21 , 22 , 23 , 24 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ) , microscopy-colocalization with upstream kinase ( 48 ) , mutation of modification site ( 48 ) , peptide sequencing ( 49 ) , phospho-antibody ( 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 13 , 14 , 17 , 18 , 19 , 45 , 46 , 49 ) , phosphoamino acid analysis ( 49 ) , phosphopeptide mapping ( 12 ) , western blotting ( 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 13 , 14 , 17 , 18 , 19 )

Relevant cell line - cell type - tissue:

'brain, brainstem' ( 16 ) , 'brain, cerebellum' ( 16 ) , 'brain, cerebral cortex' ( 5 , 14 , 16 ) , 'brain, hippocampus' ( 5 , 6 , 14 ) , 'brain, hypothalamus' ( 5 ) , 'brain, nucleus accumbens' ( 14 ) , 'brain, striatum' ( 6 , 14 , 46 ) , 'brain, visual cortex' ( 19 ) , 'neuron, cortical'-brain ( 2 , 6 ) , 'neuron, hippocampal'-brain ( 3 ) , 'neuron, hippocampal, CA1 pyramidal'-brain ( 8 ) , 293 (epithelial) ( 48 ) , brain ( 7 , 9 , 13 , 18 , 20 , 21 , 22 , 23 , 24 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ) , esophagus ( 17 ) , neuron-'brain, cerebral cortex' ( 10 ) , neuron-'brain, hippocampus' ( 4 , 15 , 49 ) , neuron-spinal cord ( 11 ) , neuron:synaptosome-brain ( 12 ) , retina ( 19 ) , spinal cord ( 45 )

Upstream Regulation
Regulatory protein:	5-HT(2A) (mouse) ( 9 ) , DRD2 (human) ( 46 ) , IL-1RA (human) ( 3 )
Putative in vivo kinases:	CAMK2A (rat) ( 17 , 46 ) , DAPK1 (rat) ( 2 , 7 ) , PKCD (human) ( 3 )
Kinases, in vitro:	CAMK2A (human) ( 46 ) , CAMK2A (rat) ( 47 , 48 , 49 )
Putative upstream phosphatases:	PPP1CA (rat) ( 13 )
Phosphatases, in vitro:	PPP1CA (human) ( 13 , 25 ) , PPP1CB (human) ( 13 ) , PPP1CC (human) ( 13 ) , PPP2CA (human) ( 25 )
Treatments:	1-methoxyoctadecan-1-ol ( 10 ) , A23187 ( 48 ) , BDE 209 ( 4 ) , bisindolylmaleimide ( 13 ) , calcineurin ( 2 , 13 ) , chronic unpredictable stress ( 7 ) , CK59 ( 2 ) , cocaine ( 46 ) , DAPK_inhibitor ( 2 ) , dark_adaptation ( 19 ) , deoxygenation ( 2 ) , DOI ( 9 ) , EGTA ( 49 ) , ethanol ( 45 ) , eticlopride ( 46 ) , ginsenoside ( 2 ) , glutamic acid ( 10 ) , Go_6983 ( 2 ) , I-2 ( 13 ) , ischemia/reperfusion ( 12 ) , ketamine ( 6 ) , KN-92 ( 46 ) , KN-93 ( 17 , 46 ) , light ( 19 ) , memantine ( 11 ) , nicotine ( 14 ) , NMDA ( 2 ) , novel object recognition test ( 8 ) , okadaic_acid ( 13 , 49 ) , PP2 ( 3 ) , quinpirole ( 46 ) , rottlerin ( 3 ) , SCH_23390 ( 46 ) , SKF81297 ( 46 ) , stress ( 8 )

Downstream Regulation
Effects of modification on NMDAR2B:	intracellular localization ( 48 ) , molecular association, regulation ( 48 ) , phosphorylation ( 3 )
Effects of modification on biological processes:	signaling pathway regulation ( 2 )
Inhibit interaction with:	CAMK2A (human) ( 48 )

Disease / Diagnostics Relevance
Relevant diseases:	hypertension ( 5 )

References
1	Lee GS, Zhang J, Wu Y, Zhou Y (2021) 14-3-3 proteins promote synaptic localization of N-methyl d-aspartate receptors (NMDARs) in mouse hippocampal and cortical neurons. PLoS One 16, e0261791 34962957 Curated Info
2	Zhang C, et al. (2020) Protopanaxadiol ginsenoside Rd protects against NMDA receptor-mediated excitotoxicity by attenuating calcineurin-regulated DAPK1 activity. Sci Rep 10, 8078 32415270 Curated Info
3	Taoro-Gonzalez L, Arenas YM, Cabrera-Pastor A, Felipo V (2018) Hyperammonemia alters membrane expression of GluA1 and GluA2 subunits of AMPA receptors in hippocampus by enhancing activation of the IL-1 receptor: underlying mechanisms. J Neuroinflammation 15, 36 29422059 Curated Info
4	Xiong L, et al. (2018) Effect of decabrominated diphenyl ether exposure on spatial learning and memory, the expression and phosphorylation of hippocampal glutamate receptor subunits in adult Sprague-Dawley rats. J Toxicol Sci 43, 645-657 30404998 Curated Info
5	Li DP, Zhou JJ, Zhang J, Pan HL (2017) CaMKII Regulates Synaptic NMDA Receptor Activity of Hypothalamic Presympathetic Neurons and Sympathetic Outflow in Hypertension. J Neurosci 37, 10690-10699 28972129 Curated Info
6	Caffino L, et al. (2017) Ketamine Self-Administration Elevates αCaMKII Autophosphorylation in Mood and Reward-Related Brain Regions in Rats. Mol Neurobiol 28948570 Curated Info
7	Li SX, et al. (2017) Uncoupling DAPK1 from NMDA receptor GluN2B subunit exerts rapid antidepressant-like effects. Mol Psychiatry 28439098 Curated Info
8	Calabrese F, et al. (2017) Chronic Mild Stress-Induced Alterations of Local Protein Synthesis: A Role for Cognitive Impairment. ACS Chem Neurosci 8, 817-825 28094500 Curated Info
9	Barre A, et al. (2016) Presynaptic serotonin 2A receptors modulate thalamocortical plasticity and associative learning. Proc Natl Acad Sci U S A 113, E1382-91 26903620 Curated Info
10	Jang JY, et al. (2014) Neuroprotective effects of a novel single compound 1-methoxyoctadecan-1-ol isolated from uncaria sinensis in primary cortical neurons and a photothrombotic ischemia model. PLoS One 9, e85322 24416390 Curated Info
11	Morel V, et al. (2013) Memantine, a promising drug for the prevention of neuropathic pain in rat. Eur J Pharmacol 721, 382-90 23810967 Curated Info
12	Zhang F, et al. (2013) Phosphorylation and assembly of glutamate receptors after brain ischemia. Stroke 44, 170-6 23212166 Curated Info
13	Prabhu Ramya R, Suma Priya S, Mayadevi M, Omkumar RV (2012) Regulation of phosphorylation at Ser(1303) of GluN2B receptor in the postsynaptic density. Neurochem Int 61, 981-5 22982438 Curated Info
14	Nakajima A, et al. (2012) Repeated treatment with nicotine induces phosphorylation of NMDA receptor NR2B subunit in the brain regions involved in behavioral sensitization. Neurosci Lett 524, 133-8 22819974 Curated Info
15	Ghafari M, et al. (2012) Mass Spectrometrical Identification of Hippocampal NMDA Receptor Subunits NR1, NR2A-D and Five Novel Phosphorylation Sites on NR2A and NR2B. J Proteome Res 11, 1891-6 22335236 Curated Info
16	Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876 22673903 Curated Info
17	Banerjee B, et al. (2011) Neuronal plasticity in the cingulate cortex of rats following esophageal acid exposure in early life. Gastroenterology 141, 544-52 21616075 Curated Info
18	Castillo C, et al. (2011) The N-methyl-D-aspartate-evoked cytoplasmic calcium increase in adult rat dorsal root ganglion neuronal somata was potentiated by substance P pretreatment in a protein kinase C-dependent manner. Neuroscience 177, 308-20 21215796 Curated Info
19	Giannakopoulos M, Kouvelas ED, Mitsacos A (2010) Experience-dependent regulation of NMDA receptor subunit composition and phosphorylation in the retina and visual cortex. Invest Ophthalmol Vis Sci 51, 1817-22 19850826 Curated Info
20	Hu Y (2010) CST Curation Set: 8874; Year: 2010; Biosample/Treatment: tissue, brain/ischemia; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
21	Hu Y (2010) CST Curation Set: 8921; Year: 2010; Biosample/Treatment: tissue, brain/ischemia; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
22	Hu Y (2010) CST Curation Set: 8875; Year: 2010; Biosample/Treatment: tissue, brain/ischemia; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
23	Hu Y (2010) CST Curation Set: 8881; Year: 2010; Biosample/Treatment: tissue, brain/ischemia; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
24	Hu Y (2010) CST Curation Set: 8880; Year: 2010; Biosample/Treatment: tissue, brain/ischemia; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
25	Raveendran R, et al. (2009) Phosphorylation status of the NR2B subunit of NMDA receptor regulates its interaction with calcium/calmodulin-dependent protein kinase II. J Neurochem 110, 92-105 19453375 Curated Info
26	Guo A (2009) CST Curation Set: 5871; Year: 2009; Biosample/Treatment: tissue, brain/No seizure; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
27	Guo A (2009) CST Curation Set: 5870; Year: 2009; Biosample/Treatment: tissue, brain/No seizure; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
28	Guo A (2009) CST Curation Set: 5867; Year: 2009; Biosample/Treatment: tissue, brain/seizure; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
29	Guo A (2009) CST Curation Set: 5868; Year: 2009; Biosample/Treatment: tissue, brain/No seizure; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
30	Guo A (2009) CST Curation Set: 5869; Year: 2009; Biosample/Treatment: tissue, brain/No seizure; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
31	Guo A (2009) CST Curation Set: 5862; Year: 2009; Biosample/Treatment: tissue, brain/sham; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
32	Guo A (2009) CST Curation Set: 5863; Year: 2009; Biosample/Treatment: tissue, brain/sham; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
33	Guo A (2009) CST Curation Set: 5864; Year: 2009; Biosample/Treatment: tissue, brain/seizure; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
34	Guo A (2009) CST Curation Set: 5865; Year: 2009; Biosample/Treatment: tissue, brain/seizure; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
35	Guo A (2009) CST Curation Set: 5866; Year: 2009; Biosample/Treatment: tissue, brain/seizure; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
36	Guo A (2009) CST Curation Set: 5861; Year: 2009; Biosample/Treatment: tissue, brain/sham; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
37	Guo A (2009) CST Curation Set: 5860; Year: 2009; Biosample/Treatment: tissue, brain/sham; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
38	Guo A (2008) CST Curation Set: 5216; Year: 2008; Biosample/Treatment: tissue, brain/mock surgery; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
39	Guo A (2008) CST Curation Set: 5217; Year: 2008; Biosample/Treatment: tissue, brain/mock surgery; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
40	Guo A (2008) CST Curation Set: 5218; Year: 2008; Biosample/Treatment: tissue, brain/mock surgery; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
41	Guo A (2008) CST Curation Set: 5219; Year: 2008; Biosample/Treatment: tissue, brain/ischemia; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
42	Guo A (2008) CST Curation Set: 5220; Year: 2008; Biosample/Treatment: tissue, brain/ischemia; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
43	Guo A (2008) CST Curation Set: 5221; Year: 2008; Biosample/Treatment: tissue, brain/ischemia; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
44	Guo A (2008) CST Curation Set: 5222; Year: 2008; Biosample/Treatment: tissue, brain/ischemia; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
45	Narita M, Miyoshi K, Narita M, Suzuki T (2007) Changes in function of NMDA receptor NR2B subunit in spinal cord of rats with neuropathy following chronic ethanol consumption. Life Sci 80, 852-9 17156796 Curated Info
46	Liu XY, et al. (2006) Modulation of D2R-NR2B interactions in response to cocaine. Neuron 52, 897-909 17145509 Curated Info
47	Mayadevi M, Praseeda M, Kumar KS, Omkumar RV (2002) Sequence determinants on the NR2A and NR2B subunits of NMDA receptor responsible for specificity of phosphorylation by CaMKII. Biochim Biophys Acta 1598, 40-5 12147342 Curated Info
48	Strack S, McNeill RB, Colbran RJ (2000) Mechanism and regulation of calcium/calmodulin-dependent protein kinase II targeting to the NR2B subunit of the N-methyl-D-aspartate receptor. J Biol Chem 275, 23798-806 10764765 Curated Info
49	Omkumar RV, et al. (1996) Identification of a phosphorylation site for calcium/calmodulindependent protein kinase II in the NR2B subunit of the N-methyl-D-aspartate receptor. J Biol Chem 271, 31670-8 8940188 Curated Info