Ser456
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Home > Phosphorylation Site Page: > Ser456  -  Chk2 (human)

Site Information
PEVWAEVsEkALDLV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 981404

In vivo Characterization
Methods used to characterize site in vivo:
flow cytometry ( 1 ) , mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 ) , lung cancer ( 1 ) , non-small cell lung cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
neocarzinostatin ( 1 )

Downstream Regulation
Effects of modification on Chk2:
protein degradation ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
apoptosis, induced ( 1 )

References 

1

Kass EM, et al. (2007) Stability of checkpoint kinase 2 is regulated via phosphorylation at serine 456. J Biol Chem 282, 30311-21
17715138   Curated Info