Thr517

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Home > Phosphorylation Site Page: > Thr517 - Chk2 (human)

Site Information
QVLAQPstSRKRPRE SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 981403

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 1 )

Upstream Regulation
Regulatory protein:	Tax (retrovirus) ( 1 )
Treatments:	ionizing_radiation ( 1 )

Downstream Regulation
Effects of modification on Chk2:	intracellular localization ( 1 )

References
1	Gupta SK, et al. (2007) Human T-cell leukemia virus type 1 Tax oncoprotein prevents DNA damage-induced chromatin egress of hyperphosphorylated Chk2. J Biol Chem 282, 29431-40 17698850 Curated Info

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