Thr378
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Home > Phosphorylation Site Page: > Thr378  -  Chk2 (human)

Site Information
HskILGEtsLMRtLC   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 981402

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 ) , mass spectrometry ( 1 , 2 , 3 ) , mutation of modification site ( 1 , 3 ) , phospho-antibody ( 1 ) , western blotting ( 1 , 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
Tax (retrovirus) ( 3 )
Treatments:
ionizing_radiation ( 1 , 3 )

Downstream Regulation
Effects of modification on Chk2:
intracellular localization ( 1 )

References 

1

Guo X, et al. (2010) Interdependent phosphorylation within the kinase domain T-loop Regulates CHK2 activity. J Biol Chem 285, 33348-57
20713355   Curated Info

2

Zhou J (2009) CST Curation Set: 7593; Year: 2009; Biosample/Treatment: cell line, HeLa/untreated; Disease: cervical adenocarcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]P
Curated Info

3

Gupta SK, et al. (2007) Human T-cell leukemia virus type 1 Tax oncoprotein prevents DNA damage-induced chromatin egress of hyperphosphorylated Chk2. J Biol Chem 282, 29431-40
17698850   Curated Info