Thr389
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Home > Phosphorylation Site Page: > Thr389  -  Chk2 (human)

Site Information
RtLCGtPtyLAPEVL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 981400

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
Tax (retrovirus) ( 2 )
Treatments:
ionizing_radiation ( 1 )

Downstream Regulation
Effects of modification on Chk2:
intracellular localization ( 1 ) , phosphorylation ( 1 )

References 

1

Guo X, et al. (2010) Interdependent phosphorylation within the kinase domain T-loop Regulates CHK2 activity. J Biol Chem 285, 33348-57
20713355   Curated Info

2

Gupta SK, et al. (2007) Human T-cell leukemia virus type 1 Tax oncoprotein prevents DNA damage-induced chromatin egress of hyperphosphorylated Chk2. J Biol Chem 282, 29431-40
17698850   Curated Info