Ser389
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Home > Phosphorylation Site Page: > Ser389  -  UBF (rat)

Site Information
INKKQTTsPASKKPS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450170

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
diabetes mellitus ( 1 )
Relevant cell line - cell type - tissue:
GEC (epithelial) ( 1 ) , kidney ( 1 ) , vascular smooth muscle cell ('muscle, smooth') ( 2 )

Upstream Regulation
Treatments:
glucose ( 1 ) , rapamycin ( 1 ) , U0126 ( 1 )

Downstream Regulation
Effects of modification on UBF:
molecular association, regulation ( 1 , 2 )
Effects of modification on biological processes:
transcription, altered ( 1 ) , transcription, induced ( 2 )
Induce interaction with:
POLR1A (rat) ( 1 ) , TIF1B (human) ( 2 )
Inhibit interaction with:
p16-INK4A iso4 (human) ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
diabetes mellitus ( 1 )

References 

1

Mariappan MM, et al. (2011) Ribosomal biogenesis induction by high glucose requires activation of upstream binding factor in kidney glomerular epithelial cells. Am J Physiol Renal Physiol 300, F219-30
20943765   Curated Info

2

Lin CH, et al. (2007) Mass spectrometric identification of phosphorylation sites of rRNA transcription factor upstream binding factor. Am J Physiol Cell Physiol 292, C1617-24
17182730   Curated Info