Ser389
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Home > Phosphorylation Site Page: > Ser389  -  UBF (mouse)

Site Information
INKKQTTsPASKKPS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450170

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , mutation of modification site ( 3 ) , phospho-antibody ( 2 ) , phosphopeptide mapping ( 3 ) , western blotting ( 2 )
Disease tissue studied:
diabetes mellitus ( 2 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 3 ) , kidney ( 2 ) , SF9 ( 3 )

Upstream Regulation
Putative in vivo kinases:
CDK2 (mouse) ( 3 )
Kinases, in vitro:
CDK2 (mouse) ( 3 )
Treatments:
glucose ( 2 )

Downstream Regulation
Effects of modification on biological processes:
transcription, altered ( 3 )

Disease / Diagnostics Relevance
Relevant diseases:
diabetes mellitus ( 2 )

References 

1

Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. Nat Commun 7, 13250
27841257   Curated Info

2

Mariappan MM, et al. (2011) Ribosomal biogenesis induction by high glucose requires activation of upstream binding factor in kidney glomerular epithelial cells. Am J Physiol Renal Physiol 300, F219-30
20943765   Curated Info

3

Voit R, Grummt I (2001) Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription. Proc Natl Acad Sci U S A 98, 13631-6
11698641   Curated Info