Ser23
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Home > Phosphorylation Site Page: > Ser23  -  SNAP23 (human)

Site Information
ItDEsLEstRRILGL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 9766096

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 3 , 4 , 5 ) , mass spectrometry (in vitro) ( 5 ) , mutation of modification site ( 5 ) , phosphoamino acid analysis ( 5 )
Disease tissue studied:
cervical cancer ( 3 ) , cervical adenocarcinoma ( 3 ) , pancreatic ductal adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:
'pancreatic, ductal'-pancreas ( 1 ) , HeLa S3 (cervical) ( 3 ) , Jurkat (T lymphocyte) ( 4 ) , K562 (erythroid) ( 2 ) , platelet-blood ( 5 )

Upstream Regulation
Kinases, in vitro:
PKCA (rat) ( 5 )

Downstream Regulation
Effects of modification on SNAP23:
molecular association, regulation ( 5 )
Induce interaction with:
STX4 (human) ( 5 )

References 

1

Britton D, et al. (2014) Quantification of pancreatic cancer proteome and phosphorylome: indicates molecular events likely contributing to cancer and activity of drug targets. PLoS One 9, e90948
24670416   Curated Info

2

Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71
23186163   Curated Info

3

Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3
20068231   Curated Info

4

Possemato A (2008) CST Curation Set: 3770; Year: 2008; Biosample/Treatment: cell line, Jurkat/pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

5

Polgár J, et al. (2003) Phosphorylation of SNAP-23 in activated human platelets. J Biol Chem 278, 44369-76
12930825   Curated Info