Ser412
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Home > Phosphorylation Site Page: > Ser412  -  ARRB1 (rat)

Site Information
EEDDGtGsPHLNNR_   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447493

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 6 ) , mass spectrometry ( 1 , 2 , 3 , 4 ) , mutation of modification site ( 1 , 6 ) , phospho-antibody ( 5 ) , phosphopeptide mapping ( 6 ) , western blotting ( 5 )
Relevant cell line - cell type - tissue:
'brain, brainstem' ( 2 ) , 'brain, cerebellum' ( 2 ) , 'brain, cerebral cortex' ( 2 ) , 'kidney, inner medulla' ( 4 ) , 293 (epithelial) [ARRB1 (human)] ( 6 ) , 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 5 ) , adipose tissue ( 2 ) , blood ( 2 ) , E.coli (bacterial) ( 1 ) , heart ( 2 ) , intestine ( 2 ) , kidney ( 2 ) , liver ( 2 , 3 ) , lung ( 2 ) , muscle ( 2 ) , spleen ( 2 ) , stomach ( 2 ) , testis ( 2 ) , thymus ( 2 )

Upstream Regulation
Treatments:
insulin ( 5 ) , isoproterenol ( 5 , 6 )

Downstream Regulation
Effects of modification on ARRB1:
intracellular localization ( 6 )

References 

1

Kang H, et al. (2020) Conformational Dynamics and Functional Implications of Phosphorylated β-Arrestins. Structure
31948726   Curated Info

2

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

3

Demirkan G, et al. (2011) Phosphoproteomic Profiling of In Vivo Signaling in Liver by the Mammalian Target of Rapamycin Complex 1 (mTORC1). PLoS One 6, e21729
21738781   Curated Info

4

Hoffert JD, et al. (2006) Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites. Proc Natl Acad Sci U S A 103, 7159-64
16641100   Curated Info

5

Hupfeld CJ, Dalle S, Olefsky JM (2003) Beta -Arrestin 1 down-regulation after insulin treatment is associated with supersensitization of beta 2 adrenergic receptor Galpha s signaling in 3T3-L1 adipocytes. Proc Natl Acad Sci U S A 100, 161-6
12509508   Curated Info

6

Lin FT, et al. (1997) Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1. J Biol Chem 272, 31051-7
9388255   Curated Info