Ser866
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Home > Phosphorylation Site Page: > Ser866  -  NFkB-p100 (human)

Site Information
tAEVkEDsAyGsQsV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450166

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 5 ) , mutation of modification site ( 3 , 4 , 5 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 , 3 )
Disease tissue studied:
bone cancer ( 1 ) , colorectal cancer ( 3 ) , colorectal carcinoma ( 3 ) , lymphoma ( 3 ) , B cell lymphoma ( 3 ) , prostate cancer ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 , 4 , 5 ) , DU 145 (prostate cell) ( 1 ) , HCAEC (endothelial) ( 1 ) , HCT116 (intestinal) ( 3 ) , M12 (B lymphocyte) ( 3 ) , U2OS (bone cell) ( 1 )

Upstream Regulation
Regulatory protein:
IKKB (human) ( 1 ) , Nik (human) ( 3 )
Putative in vivo kinases:
IKKA (human) ( 1 )
Kinases, in vitro:
IKKA (human) ( 3 ) , Nik (human) ( 5 )
Treatments:
antibody ( 3 ) , CW15337 ( 1 ) , GSK-3_inhibitor_IX ( 2 ) , IKK2-X1 ( 1 ) , IL-1b ( 1 ) , Lymphotoxin LTA1B2 ( 1 ) , siRNA ( 1 ) , TNF ( 1 )

Downstream Regulation
Effects of modification on NFkB-p100:
molecular association, regulation ( 2 , 4 ) , protein processing ( 5 )
Induce interaction with:
BTRC (human) ( 2 ) , IKKA (human) ( 4 )

References 

1

McIntosh K, et al. (2023) IL-1β stimulates a novel, IKKα -dependent, NIK -independent activation of non-canonical NFκB signalling. Cell Signal 107, 110684
37080443   Curated Info

2

Busino L, et al. (2012) Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma. Nat Cell Biol 14, 375-85
22388891   Curated Info

3

Vatsyayan J, Qing G, Xiao G, Hu J (2008) SUMO1 modification of NF-kappaB2/p100 is essential for stimuli-induced p100 phosphorylation and processing. EMBO Rep 9, 885-90
18617892   Curated Info

4

Qu Z, Qing G, Rabson A, Xiao G (2004) Tax deregulation of NF-kappaB2 p100 processing involves both beta-TrCP-dependent and -independent mechanisms. J Biol Chem 279, 44563-72
15310758   Curated Info

5

Xiao G, Harhaj EW, Sun SC (2001) NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100. Mol Cell 7, 401-9
11239468   Curated Info

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