Ser271
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Home > Phosphorylation Site Page: > Ser271  -  Tau iso3 (human)

Site Information
GAEIVYKsPVVSGDT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449081

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
adrenal cancer ( 1 ) , pheochromocytoma ( 1 )
Relevant cell line - cell type - tissue:
brain ( 2 ) , CHO (fibroblast) ( 2 ) , PC-12 (chromaffin) ( 1 )

Upstream Regulation
Treatments:
okadaic_acid ( 1 )

Downstream Regulation
Effects of modification on Tau iso3:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 1 )

References 

1

Maas T, Eidenm├╝ller J, Brandt R (2000) Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments. J Biol Chem 275, 15733-40
10747907   Curated Info

2

Bramblett GT, et al. (1993) Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding. Neuron 10, 1089-99
8318230   Curated Info