Thr35
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Home > Phosphorylation Site Page: > Thr35  -  PDE6G (cow)

Site Information
PKFKQRQtRQFKSKP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450149

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
retina ( 1 )

Upstream Regulation
Kinases, in vitro:
PKACA (cow) ( 2 ) , PKCA (cow) ( 3 )
Treatments:
dark_adaptation ( 1 ) , light ( 1 )

Downstream Regulation
Effects of modification on PDE6G:
phosphorylation ( 1 )

References 

1

Janisch KM, et al. (2009) Light-dependent phosphorylation of the gamma subunit of cGMP-phophodiesterase (PDE6gamma) at residue threonine 22 in intact photoreceptor neurons. Biochem Biophys Res Commun 390, 1149-53
19878658   Curated Info

2

Paglia MJ, Mou H, Cote RH (2002) Regulation of photoreceptor phosphodiesterase (PDE6) by phosphorylation of its inhibitory gamma subunit re-evaluated. J Biol Chem 277, 5017-23
11741972   Curated Info

3

Udovichenko IP, Cunnick J, Gonzalez K, Takemoto DJ (1994) Functional effect of phosphorylation of the photoreceptor phosphodiesterase inhibitory subunit by protein kinase C. J Biol Chem 269, 9850-6
8144577   Curated Info