Lys280

Site Information
IsQsAPVkQPPPLAP SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 964556212

In vivo Characterization
Methods used to characterize site in vivo:	flow cytometry ( 1 ) , immunoprecipitation ( 1 , 2 ) , mass spectrometry ( 2 , 3 ) , mutation of modification site ( 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:	gastric cancer ( 1 , 2 ) , gastric carcinoma ( 1 , 2 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 1 ) , AGS (gastric) ( 1 ) , HEK293T (epithelial) ( 2 ) , HEp-2 (squamous) ( 3 ) , MGC803 (gastric) ( 2 ) , MKN-28 (gastric) ( 1 ) , SGC7901 (gastric) ( 2 )

Downstream Regulation
Effects of modification on YAP1:	protein degradation ( 1 , 2 )
Effects of modification on biological processes:	carcinogenesis, altered ( 1 ) , carcinogenesis, inhibited ( 2 ) , cell growth, inhibited ( 2 )

References
1	Yan C, et al. (2022) OTUB1 suppresses Hippo signaling via modulating YAP protein in gastric cancer. Oncogene 36271031 Curated Info
2	Tang DE, et al. (2019) STUB1 suppresseses tumorigenesis and chemoresistance through antagonizing YAP1 signaling. Cancer Sci 110, 3145-3156 31393050 Curated Info
3	Akimov V, et al. (2018) UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites. Nat Struct Mol Biol 25, 631-640 29967540 Curated Info