His266
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Home > Phosphorylation Site Page: > His266  -  G-beta 1 (human)

Site Information
QELMTYShDNIICGI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 9643001

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 4 ) , peptide sequencing ( 4 ) , western blotting ( 3 )
Relevant cell line - cell type - tissue:
brain ( 4 ) , H10 (myocyte) ( 3 )

Upstream Regulation
Putative upstream phosphatases:
PHPT1 (human) ( 3 )
Phosphatases, in vitro:
PHPT1 (human) ( 3 )

Downstream Regulation
Effects of modification on G-beta 1:
activity, induced ( 4 )

References 

1

Hippe HJ, et al. (2007) Regulation of cardiac cAMP synthesis and contractility by nucleoside diphosphate kinase B/G protein beta gamma dimer complexes. Circ Res 100, 1191-9
17363702   Curated Info

2

Mosharov EV, et al. (2006) Alpha-synuclein overexpression increases cytosolic catecholamine concentration. J Neurosci 26, 9304-11
16957086   Curated Info

3

Mäurer A, et al. (2005) The beta-subunit of G proteins is a substrate of protein histidine phosphatase. Biochem Biophys Res Commun 334, 1115-20
16039992   Curated Info

4

Cuello F, et al. (2003) Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta. J Biol Chem 278, 7220-6
12486123   Curated Info