Tyr529
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Home > Phosphorylation Site Page: > Tyr529  -  Src (mouse)

Site Information
FTSTEPQyQPGENL_   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448235
Associated spectra:  2 CST

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 6 ) , mass spectrometry ( 5 ) , phospho-antibody ( 1 , 3 , 4 , 6 ) , western blotting ( 1 , 3 , 4 , 6 )
Disease tissue studied:
testicular cancer ( 6 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
caveolin-1 (mouse) ( 4 ) , CSK (mouse) ( 3 ) , MTSS1 (human) ( 1 ) , PTPRD (human) ( 1 )
Putative upstream phosphatases:
PTPRA (human) ( 6 )
Phosphatases, in vitro:
PTPRA (human) ( 6 )
Treatments:
PDGF ( 7 ) , retinoic_acid ( 6 )

Downstream Regulation
Effects of modification on Src:
enzymatic activity, inhibited ( 1 , 6 )
Effects of modification on biological processes:
cell differentiation, altered ( 6 ) , cell differentiation, inhibited ( 1 )

References 

1

Chen M, et al. (2023) Metastasis suppressor 1 interacts with protein tyrosine phosphatase receptor-δ to regulate adipogenesis. FASEB J 37, e22857
36906292   Curated Info

2

Pan Q, et al. (2011) Cdk5 targets active Src for ubiquitin-dependent degradation by phosphorylating Src(S75). Cell Mol Life Sci 68, 3425-36
21442427   Curated Info

3

Oneyama C, et al. (2008) The lipid raft-anchored adaptor protein Cbp controls the oncogenic potential of c-Src. Mol Cell 30, 426-36
18498747   Curated Info

4

Patel HH, et al. (2007) Mechanisms of cardiac protection from ischemia/reperfusion injury: a role for caveolae and caveolin-1. FASEB J 21, 1565-74
17272740   Curated Info

5

Moritz A (2003) CST Curation Set: 208; Year: 2003; Biosample/Treatment: cell line, 3T3/NRG1; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

6

den Hertog J, et al. (1993) Receptor protein tyrosine phosphatase alpha activates pp60c-src and is involved in neuronal differentiation. EMBO J 12, 3789-98
7691597   Curated Info

7

Gould KL, Hunter T (1988) Platelet-derived growth factor induces multisite phosphorylation of pp60c-src and increases its protein-tyrosine kinase activity. Mol Cell Biol 8, 3345-56
2463476   Curated Info