Ser177
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Home > Phosphorylation Site Page: > Ser177  -  IKKB (mouse)

Site Information
AKELDQGsLCTsFVG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447492

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 3 , 7 ) , phospho-antibody ( 1 , 2 , 5 , 6 , 7 , 8 ) , western blotting ( 1 , 2 , 5 , 6 , 7 , 8 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , colon ( 2 , 6 , 8 ) , HeLa (cervical) ( 1 ) , macrophage ( 7 ) , MEF (fibroblast) ( 3 ) , microvessel endothelial-lung ( 5 ) , monocyte ( 7 ) , osteoclast ( 7 )

Upstream Regulation
Regulatory protein:
ILK (mouse) ( 2 ) , SNX8 (mouse) ( 1 )
Putative in vivo kinases:
AMPKA2 (mouse) ( 5 )
Treatments:
bacterial infection ( 6 , 8 ) , bortezomib ( 8 ) , IFN-gamma ( 1 ) , nitric_oxide ( 4 ) , PD98059 ( 6 ) , RANKL ( 7 ) , TNF ( 7 )

Downstream Regulation
Effects of modification on IKKB:
enzymatic activity, induced ( 7 ) , phosphorylation ( 3 )
Effects of modification on biological processes:
cell differentiation, induced ( 7 )

References 

1

Wei J, et al. (2017) SNX8 mediates IFNγ-triggered noncanonical signaling pathway and host defense against Listeria monocytogenes. Proc Natl Acad Sci U S A 114, 13000-13005
29180417   Curated Info

2

Ahmed AU, et al. (2017) Integrin-Linked Kinase Expression in Myeloid Cells Promotes Inflammatory Signaling during Experimental Colitis. J Immunol
28794235   Curated Info

3

Yan J, et al. (2013) Inactivation of BAD by IKK inhibits TNFα-induced apoptosis independently of NF-κB activation. Cell 152, 304-15
23332762   Curated Info

4

Sarkar S, et al. (2011) Complex inhibitory effects of nitric oxide on autophagy. Mol Cell 43, 19-32
21726807   Curated Info

5

Bess E, Fisslthaler B, Frömel T, Fleming I (2011) Nitric oxide-induced activation of the AMP-activated protein kinase α2 subunit attenuates IκB kinase activity and inflammatory responses in endothelial cells. PLoS One 6, e20848
21673972   Curated Info

6

Chandrakesan P, et al. (2010) Novel changes in NF-{kappa}B activity during progression and regression phases of hyperplasia: role of MEK, ERK, and p38. J Biol Chem 285, 33485-98
20710027   Curated Info

7

Darwech I, Otero JE, Alhawagri MA, Abu-Amer Y (2010) Tyrosine phosphorylation is required for IkappaB kinase-beta (IKKbeta) activation and function in osteoclastogenesis. J Biol Chem 285, 25522-30
20534585   Curated Info

8

Wang Y, Xiang GS, Kourouma F, Umar S (2006) Citrobacter rodentium-induced NF-kappaB activation in hyperproliferating colonic epithelia: role of p65 (Ser536) phosphorylation. Br J Pharmacol 148, 814-24
16751795   Curated Info