Thr485
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Home > Phosphorylation Site Page: > Thr485  -  SRPK2 (rat)

Site Information
PSRDRSRtVsASstG   GenPept Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 483237

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
'neuron, cortical' ( 2 ) , 293FT ( 1 ) , brain ( 1 ) , HeLa (cervical) ( 1 )

Downstream Regulation
Effects of modification on biological processes:
apoptosis, altered ( 2 )

References 

1

Wang ZH, et al. (2017) Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer's Disease. Mol Cell 67, 812-825.e5
28826672   Curated Info

2

Jang SW, et al. (2009) Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons. J Biol Chem 284, 24512-25
19592491   Curated Info