Thr485
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Home > Phosphorylation Site Page: > Thr485  -  SRPK2 (mouse)

Site Information
PsHDRsRtVsAsstG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 483237

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , immunoprecipitation ( 1 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:
'brain, hippocampus' ( 1 ) , 'neuron, cortical' ( 2 ) , 293 (epithelial) ( 1 ) , brain ( 1 ) , kidney ( 1 ) , SH-SY5Y (neural crest) ( 1 )

Upstream Regulation
Regulatory protein:
LGMN (human) ( 1 )
Putative in vivo kinases:
SRPK2 (human) ( 1 )
Treatments:
development ( 1 ) , ischemia ( 2 )

Downstream Regulation
Effects of modification on SRPK2:
enzymatic activity, induced ( 1 ) , intracellular localization ( 1 ) , phosphorylation ( 1 )
Effects of modification on biological processes:
transcription, altered ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
Alzheimer's disease ( 1 )

References 

1

Wang ZH, et al. (2018) Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies. J Exp Med
30373880   Curated Info

2

Jang SW, et al. (2009) Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons. J Biol Chem 284, 24512-25
19592491   Curated Info