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IsLELPLsQEtFsGL SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 447490 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
Disease tissue studied: | |
Relevant cell line - cell type - tissue: |
Upstream Regulation | |
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Regulatory protein: | |
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Kinases, in vitro: | |
Putative upstream phosphatases: | |
Phosphatases, in vitro: | |
Treatments: |
Downstream Regulation | |
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Effects of modification on p53: | |
Effects of modification on biological processes: | |
Induce interaction with: |
Disease / Diagnostics Relevance | |
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Relevant diseases: |
References | |
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Zhang C, et al. (2023) Proximal Tubular Ablation Exacerbates Ischemia/Reperfusion Injury (IRI)-Induced Renal Maladaptive Repair through the Upregulation of P53. Int J Mol Sci 24
37894939 Curated Info |
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Attaway AH, et al. (2023) Adaptive exhaustion during prolonged intermittent hypoxia causes dysregulated skeletal muscle protein homeostasis. J Physiol 601, 567-606
36533558 Curated Info |
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Haarer EL, et al. (2023) Genomic instability caused by Arp2/3 complex inactivation results in micronucleus biogenesis and cellular senescence. PLoS Genet 19, e1010045
36706133 Curated Info |
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Kang J, et al. (2022) EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer. Cell Rep 41, 111827
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Yoshida A, et al. (2022) Non-phosphorylatable cyclin D1 mutant potentiates endometrial hyperplasia and drives carcinoma with Pten loss. Oncogene 41
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Carlini MJ, Triplett MK, Pellizzoni L (2022) Neuromuscular denervation and deafferentation but not motor neuron death are disease features in the Smn2B/- mouse model of SMA. PLoS One 17, e0267990
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Wang X, et al. (2021) CDK5RAP2 loss-of-function causes premature cell senescence via the GSK3β/β-catenin-WIP1 pathway. Cell Death Dis 13, 9
34930892 Curated Info |
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Kutle I, et al. (2020) Murine Cytomegalovirus M25 Proteins Sequester the Tumor Suppressor Protein p53 in Nuclear Accumulations. J Virol
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Nakazawa H, et al. (2017) iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-κB and p53. PLoS One 12, e0170391
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Wang X, et al. (2015) Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation. Sci Rep 5, 8566
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Zhao J, et al. (2015) Foxp1 Regulates the Proliferation of Hair Follicle Stem Cells in Response to Oxidative Stress during Hair Cycling. PLoS One 10, e0131674
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Bunimovich YL, et al. (2014) Deoxycytidine Kinase Augments ATM-Mediated DNA Repair and Contributes to Radiation Resistance. PLoS One 9, e104125
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Seong HA, Ha H (2012) Murine Protein Serine-threonine Kinase 38 Activates p53 Function through Ser15 Phosphorylation. J Biol Chem 287, 20797-810
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Assaily W, et al. (2011) ROS-mediated p53 induction of Lpin1 regulates fatty acid oxidation in response to nutritional stress. Mol Cell 44, 491-501
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Mehta S, et al. (2011) The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma. Cancer Cell 19, 359-71
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Lee MK, Tong WM, Wang ZQ, Sabapathy K (2011) Serine 312 phosphorylation is dispensable for wild-type p53 functions in vivo. Cell Death Differ 18, 214-21
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Wang X, et al. (2011) A positive role for c-Abl in Atm and Atr activation in DNA damage response. Cell Death Differ 18, 5-15
20798688 Curated Info |
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George J, et al. (2011) Resveratrol and black tea polyphenol combination synergistically suppress mouse skin tumors growth by inhibition of activated MAPKs and p53. PLoS One 6, e23395
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Mason EF, et al. (2010) Aerobic glycolysis suppresses p53 activity to provide selective protection from apoptosis upon loss of growth signals or inhibition of BCR-Abl. Cancer Res 70, 8066-76
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Yang J, et al. (2010) Conditional ablation of Ikkb inhibits melanoma tumor development in mice. J Clin Invest 120, 2563-74
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Nam C, Doi K, Nakayama H (2010) Etoposide induces G2/M arrest and apoptosis in neural progenitor cells via DNA damage and an ATM/p53-related pathway. Histol Histopathol 25, 485-93
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Sluss HK, et al. (2010) Phosphorylation of p53 serine 18 upregulates apoptosis to suppress Myc-induced tumorigenesis. Mol Cancer Res 8, 216-22
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LaGory EL, Sitailo LA, Denning MF (2010) The protein kinase Cdelta catalytic fragment is critical for maintenance of the G2/M DNA damage checkpoint. J Biol Chem 285, 1879-87
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Chen P, et al. (2010) Jnk2 effects on tumor development, genetic instability and replicative stress in an oncogene-driven mouse mammary tumor model. PLoS One 5, e10443
20454618 Curated Info |
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Skorta I, et al. (2009) Imatinib mesylate induces cisplatin hypersensitivity in Bcr-Abl+ cells by differential modulation of p53 transcriptional and proapoptotic activity. Cancer Res 69, 9337-45
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Calabrese V, et al. (2009) SOCS1 links cytokine signaling to p53 and senescence. Mol Cell 36, 754-67
20005840 Curated Info |
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Nogueira V, et al. (2008) Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. Cancer Cell 14, 458-70
19061837 Curated Info |
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Daniel JA, et al. (2008) Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo. J Cell Biol 183, 777-83
19047460 Curated Info |
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Warnock LJ, et al. (2008) Influence of tetramerisation on site-specific post-translational modifications of p53: comparison of human and murine p53 tumor suppressor protein. Cancer Biol Ther 7, 1481-9
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Wang WH, Hullinger RL, Andrisani OM (2008) Hepatitis B virus X protein via the p38MAPK pathway induces E2F1 release and ATR kinase activation mediating p53 apoptosis. J Biol Chem 283, 25455-67
18606816 Curated Info |
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Hitomi M, Yang K, Stacey AW, Stacey DW (2008) Phosphorylation of cyclin D1 regulated by ATM or ATR controls cell cycle progression. Mol Cell Biol 28, 5478-93
18606783 Curated Info |
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Shields BJ, et al. (2008) DNA replication stalling attenuates tyrosine kinase signaling to suppress S phase progression. Cancer Cell 14, 166-79
18691551 Curated Info |
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Tchivilev I, et al. (2008) Identification of a protective role for protein phosphatase 1cgamma1 against oxidative stress-induced vascular smooth muscle cell apoptosis. J Biol Chem 283, 22193-205
18540044 Curated Info |
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Stracker TH, et al. (2008) Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage. Mol Cell 31, 21-32
18614044 Curated Info |
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Qin J, et al. (2008) Protein phosphatase-2A is a target of epigallocatechin-3-gallate and modulates p53-Bak apoptotic pathway. Cancer Res 68, 4150-62
18519674 Curated Info |
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Mohanty S, et al. (2008) Defective p53 engagement after the induction of DNA damage in cells deficient in topoisomerase 3beta. Proc Natl Acad Sci U S A 105, 5063-8
18367668 Curated Info |
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Armata HL, Garlick DS, Sluss HK (2007) The ataxia telangiectasia-mutated target site Ser18 is required for p53-mediated tumor suppression. Cancer Res 67, 11696-703
18089799 Curated Info |
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Li N, et al. (2007) Adaptor protein LAPF recruits phosphorylated p53 to lysosomes and triggers lysosomal destabilization in apoptosis. Cancer Res 67, 11176-85
18056442 Curated Info |
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Yang YG, Lindahl T, Barnes DE (2007) Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease. Cell 131, 873-86
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Kremer BE, Adang LA, Macara IG (2007) Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7. Cell 130, 837-50
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17596534 Curated Info |
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Itoh T, et al. (2007) Ddb2 is a haploinsufficient tumor suppressor and controls spontaneous germ cell apoptosis. Hum Mol Genet 16, 1578-86
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Tomimatsu N, et al. (2007) Ku70/80 modulates ATM and ATR signaling pathways in response to DNA double strand breaks. J Biol Chem 282, 10138-45
17272272 Curated Info |
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Limesand KH, Schwertfeger KL, Anderson SM (2006) MDM2 is required for suppression of apoptosis by activated Akt1 in salivary acinar cells. Mol Cell Biol 26, 8840-56
16982679 Curated Info |
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Cecchinelli B, et al. (2006) Ser58 of mouse p53 is the homologue of human Ser46 and is phosphorylated by HIPK2 in apoptosis. Cell Death Differ 13, 1994-7
16729035 Curated Info |
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Shi X, et al. (2006) CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. Immunity 25, 595-606
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Shreeram S, et al. (2006) Wip1 phosphatase modulates ATM-dependent signaling pathways. Mol Cell 23, 757-64
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Chao C, Herr D, Chun J, Xu Y (2006) Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression. EMBO J 25, 2615-22
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Blanco S, Klimcakova L, Vega FM, Lazo PA (2006) The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines. FEBS J 273, 2487-504
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Wu D, et al. (2006) ERK activity facilitates activation of the S-phase DNA damage checkpoint by modulating ATR function. Oncogene 25, 1153-64
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Brown L, Benchimol S (2006) The involvement of MAPK signaling pathways in determining the cellular response to p53 activation: cell cycle arrest or apoptosis. J Biol Chem 281, 3832-40
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