Thr253
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Home > Phosphorylation Site Page: > Thr253  -  PTP-SL iso2 (mouse)

Site Information
EPFVAVStPREKVAM   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450119

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:
COS (fibroblast) [PTP-SL iso2 (mouse)] ( 1 )

Upstream Regulation
Putative in vivo kinases:
ERK1 (human) ( 1 ) , ERK2 (human) ( 1 )
Kinases, in vitro:
ERK1 (rat) ( 1 ) , ERK2 (rat) ( 1 )
Treatments:
EGF ( 1 ) , PD98059 ( 1 )

Downstream Regulation
Effects of modification on PTP-SL iso2:
molecular association, regulation ( 1 )

References 

1

Pulido R, Zúñiga A, Ullrich A (1998) PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif. EMBO J 17, 7337-50
9857190   Curated Info