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Site Information |
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MsIELPLsQEtFsCL SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 447490 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
Disease tissue studied: | |
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Upstream Regulation | |
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Downstream Regulation | |
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Effects of modification on p53: | |
Effects of modification on biological processes: |
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Relevant diseases: |
References | |
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Kim DE, et al. (2022) Plk2-mediated phosphorylation and translocalization of Nrf2 activates anti-inflammation through p53/Plk2/p21 signaling in acute kidney injury. Cell Biol Toxicol
35842499 Curated Info |
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Wu WY, et al. (2022) SSBP1 drives high fructose-induced glomerular podocyte ferroptosis via activating DNA-PK/p53 pathway. Redox Biol 52, 102303
35390676 Curated Info |
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Nguyen MT, et al. (2022) The matricellular protein CCN5 induces apoptosis in myofibroblasts through SMAD7-mediated inhibition of NFκB. PLoS One 17, e0269735
35917315 Curated Info |
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Nie J, et al. (2021) Phosphorylation of p53 by Cdk5 contributes to benzo[a]pyrene-induced neuronal apoptosis. Environ Toxicol
34529316 Curated Info |
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Uhlemeyer C, et al. (2020) ATM and P53 differentially regulate pancreatic beta cell survival in Ins1E cells. PLoS One
32810137 Curated Info |
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Wilson AM, et al. (2014) Inhibitor of Apoptosis-Stimulating Protein of p53 (iASPP) Is Required for Neuronal Survival after Axonal Injury. PLoS One 9, e94175
24714389 Curated Info |
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Gogna R, et al. (2013) p53's choice of myocardial death or survival: Oxygen protects infarct myocardium by recruiting p53 on NOS3 promoter through regulation of p53-Lys(118) acetylation. EMBO Mol Med 5, 1662-83
24096875 Curated Info |
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Pizarro JG, et al. (2010) ATM is involved in cell-cycle control through the regulation of retinoblastoma protein phosphorylation. J Cell Biochem 110, 210-8
20213763 Curated Info |
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Restle A, et al. (2008) Dissecting the role of p53 phosphorylation in homologous recombination provides new clues for gain-of-function mutants. Nucleic Acids Res 36, 5362-75
18697815 Curated Info |
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Zhang XH, Zhao C, Ma ZA (2007) The increase of cell-membranous phosphatidylcholines containing polyunsaturated fatty acid residues induces phosphorylation of p53 through activation of ATR. J Cell Sci 120, 4134-43
18032786 Curated Info |
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Lee YS, et al. (2006) Ubiquitin-dependent degradation of p53 protein despite phosphorylation at its N terminus by acetaminophen. J Pharmacol Exp Ther 317, 202-8
16330492 Curated Info |
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Grishko V, et al. (2003) Apoptotic cascade initiated by angiotensin II in neonatal cardiomyocytes: role of DNA damage. Am J Physiol Heart Circ Physiol 285, H2364-72
12919932 Curated Info |
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Fogarty MP, Downer EJ, Campbell V (2003) A role for c-Jun N-terminal kinase 1 (JNK1), but not JNK2, in the beta-amyloid-mediated stabilization of protein p53 and induction of the apoptotic cascade in cultured cortical neurons. Biochem J 371, 789-98
12534344 Curated Info |
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Haider UG, et al. (2003) Resveratrol increases serine15-phosphorylated but transcriptionally impaired p53 and induces a reversible DNA replication block in serum-activated vascular smooth muscle cells. Mol Pharmacol 63, 925-32
12644594 Curated Info |
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Fiordaliso F, et al. (2001) Hyperglycemia activates p53 and p53-regulated genes leading to myocyte cell death. Diabetes 50, 2363-75
11574421 Curated Info |