Ser581
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Home > Phosphorylation Site Page: > Ser581  -  B-Myb (mouse)

Site Information
RKPGLRRsPIKKVRK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450115

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 3 ) , [32P] bio-synthetic labeling ( 2 , 3 , 4 ) , immunoprecipitation ( 2 ) , mutation of modification site ( 2 , 4 ) , peptide sequencing ( 2 ) , phosphoamino acid analysis ( 2 ) , phosphopeptide mapping ( 4 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 3 ) , COS (fibroblast) ( 2 ) , HEK293T (epithelial) ( 2 ) , U2OS (bone cell) [GR (human)] ( 4 )

Upstream Regulation
Kinases, in vitro:
CDK2 (mouse) ( 1 , 2 , 4 )

Downstream Regulation
Effects of modification on B-Myb:
activity, induced ( 4 )
Effects of modification on biological processes:
transcription, induced ( 2 )

References 

1

Müller-Tidow C, et al. (2001) Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function. Blood 97, 2091-7
11264176   Curated Info

2

Johnson TK, Schweppe RE, Septer J, Lewis RE (1999) Phosphorylation of B-Myb regulates its transactivation potential and DNA binding. J Biol Chem 274, 36741-9
10593981   Curated Info

3

Bartsch O, et al. (1999) Identification of cyclin A/Cdk2 phosphorylation sites in B-Myb. Eur J Biochem 260, 384-91
10095772   Curated Info

4

Saville MK, Watson RJ (1998) The cell-cycle regulated transcription factor B-Myb is phosphorylated by cyclin A/Cdk2 at sites that enhance its transactivation properties. Oncogene 17, 2679-89
9840932   Curated Info

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