Tyr220
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Home > Phosphorylation Site Page: > Tyr220  -  myelin P0 (human)

Site Information
GRQtPVLyAMLDHsR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450106

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 ) , mutation of modification site ( 3 , 4 ) , phospho-antibody ( 4 ) , western blotting ( 4 )
Disease tissue studied:
gastric cancer ( 2 ) , fibrosarcoma of soft tissue ( 4 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 4 ) , FU97 (gastric) ( 2 ) , HT1080 (fibroblast) ( 4 ) , Rsc96 (neuron) ( 3 )

Upstream Regulation
Treatments:
vanadate ( 4 )

Downstream Regulation
Effects of modification on myelin P0:
molecular association, regulation ( 4 )

References 

1

Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96
23911959   Curated Info

2

Ren H (2010) CST Curation Set: 9101; Year: 2010; Biosample/Treatment: cell line, FU97/Gleevec; Disease: gastric cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

3

Konde V, Eichberg J (2006) Myelin protein zero: mutations in the cytoplasmic domain interfere with its cellular trafficking. J Neurosci Res 83, 957-64
16493674   Curated Info

4

Xu M, et al. (2000) Tyrosine phosphorylation of myelin P(0) and its implication in signal transduction. Biochem Biophys Res Commun 267, 820-5
10673375   Curated Info