Ser181
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Home > Phosphorylation Site Page: > Ser181  -  IKKB (rat)

Site Information
DQGsLCTsFVGTLQY   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447489

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 4 ) , phospho-antibody ( 1 , 2 , 5 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
'brain, hippocampus' ( 2 ) , Fao (hepatic) ( 4 ) , PC-12 (chromaffin) ( 5 ) , VSMC ('muscle, smooth') ( 1 )

Upstream Regulation
Regulatory protein:
IKKB (rat) ( 4 ) , p90RSK (rat) ( 1 ) , PKCA (rat) ( 1 ) , PKCE (rat) ( 4 ) , RSK2 (rat) ( 1 ) , RSK3 (rat) ( 1 ) , TAK1 (rat) ( 1 ) , TRAF6 (rat) ( 1 )
Treatments:
angiotensin_2 ( 1 ) , anisomycin ( 4 ) , BAPTA-AM ( 1 ) , contextual fear conditioning ( 2 ) , DDTC ( 2 ) , Go_6976 ( 1 ) , insulin ( 4 ) , NGF ( 5 ) , palmitate ( 4 ) , PD184352 ( 1 ) , PDGF ( 1 ) , phorbol_ester ( 4 ) , U0126 ( 1 )

Downstream Regulation
Effects of modification on IKKB:
enzymatic activity, induced ( 5 )
Effects of modification on biological processes:
cell growth, altered ( 5 )

References 

1

Doyon P, Servant MJ (2010) Tumor necrosis factor receptor-associated factor-6 and ribosomal S6 kinase intracellular pathways link the angiotensin II AT1 receptor to the phosphorylation and activation of the IkappaB kinase complex in vascular smooth muscle cells. J Biol Chem 285, 30708-18
20659889   Curated Info

2

Lubin FD, Sweatt JD (2007) The IkappaB kinase regulates chromatin structure during reconsolidation of conditioned fear memories. Neuron 55, 942-57
17880897   Curated Info

3

Tang CH, et al. (2007) Leptin-induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 pathway in microglia. J Immunol 179, 1292-302
17617622   Curated Info

4

Herschkovitz A, et al. (2007) Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance. J Biol Chem 282, 18018-27
17446166   Curated Info

5

Azoitei N, Wirth T, Baumann B (2005) Activation of the IkappaB kinase complex is sufficient for neuronal differentiation of PC12 cells. J Neurochem 93, 1487-501
15935065   Curated Info