Ser115
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Home > Phosphorylation Site Page: > Ser115  -  CREB (human)

Site Information
QKRREILsRRPsyRk   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450092

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 , 3 ) , mutation of modification site ( 1 , 4 ) , phospho-antibody ( 1 , 5 ) , western blotting ( 1 , 5 )
Disease tissue studied:
gastric cancer ( 2 ) , gastric carcinoma ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
GSK3B (human) ( 1 )
Treatments:
colforsin ( 4 ) , SB216763 ( 1 ) , TNF ( 5 )

Downstream Regulation
Effects of modification on CREB:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
cell growth, induced ( 1 ) , transcription, induced ( 1 )
Induce interaction with:
MEIS1 (human) ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
prostate cancer ( 5 )

References 

1

Wang Z, et al. (2010) GSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesis. Cancer Cell 17, 597-608
20541704   Curated Info

2

Moritz A (2010) CST Curation Set: 9235; Year: 2010; Biosample/Treatment: cell line, MKN-45/calyculin_A & pervanadate; Disease: gastric carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY])
Curated Info

3

Zhou J (2008) CST Curation Set: 5309; Year: 2008; Biosample/Treatment: cell line, Jurkat/untreated; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: (K/R)XpSX(K/R)Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser) PKC Substrate Antibody Cat#: 2261, PTMScan(R) Phospho-PKC Substrate Motif (K/RXpSXK/R) Immunoaffinity Beads Cat#: 1985
Curated Info

4

Hansen TO, Rehfeld JF, Nielsen FC (2004) GSK-3beta reduces cAMP-induced cholecystokinin gene expression by inhibiting CREB binding. Neuroreport 15, 841-5
15073527   Curated Info

5

Salas TR, et al. (2003) Alleviating the suppression of glycogen synthase kinase-3beta by Akt leads to the phosphorylation of cAMP-response element-binding protein and its transactivation in intact cell nuclei. J Biol Chem 278, 41338-46
12900420   Curated Info

6

Fiol CJ, et al. (1994) A secondary phosphorylation of CREB341 at Ser129 is required for the cAMP-mediated control of gene expression. A role for glycogen synthase kinase-3 in the control of gene expression. J Biol Chem 269, 32187-93
7798217   Curated Info